What does laxogenin do to your body?
As dietary supplements, laxogenin and its so-called derivative, 5-alpha-hydroxy-laxogenin, are promoted as “natural anabolics” (alternatives to anabolic steroids) for those who want to gain muscle mass while keeping body fat low.As dietary supplements, laxogenin and its so-called derivative, 5-alpha-hydroxy-laxogenin, are promoted as “natural anabolics” (alternatives to anabolic steroids) for those who want to gain muscle mass while keeping body fat low.
What is Smilax used for?
Smilax glabra is known as Tufuling in traditional Chinese medicine. The root has been used in combination with other herbs to treat various types of infections and inflammatory conditions. Lab studies suggest this plant has anti-inflammatory and anticancer properties. Various smilax extracts have demonstrated anti-inflammatory and antimicrobial properties, as well as effects on cardiovascular risk factors and metabolic syndrome; however, evidence is based largely on animal and in vitro studies, and clinical trials are limited.
Is laxogenin a myostatin inhibitor?
In this study, laxogenin (LAX) and 5-alpha-hydroxy-laxogenin (5HLAX) were computationally screened against myostatin (MSTN), a negative regulator of muscle mass, because of their antioxidant properties and dual roles as MSTN inhibitors and enhancers of myogenesis regulatory factors. At a concentration of 10 nM, LAX and 5HLAX effectively inhibited the mRNA and protein expressions of MSTN, promoted myogenesis, and enhanced myotube formation and maturation. In addition, by acting as agonists of ROS downregulating factors, they exhibited antioxidative effects.