What is the mechanism of action of metformin?
What is the mechanism of action of metformin? Molecular mechanisms of the mitochondrial action of metformin. Metformin exerts mild, transient and specific inhibition of complex I (NADH:ubiquinone oxidoreductase) of the respiratory chain, which leads to a change in both AMP/ATP ratio and NAD+/NADH ratio, effects that lead to downregulation of gluconeogenesis. The main sign that […]
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