December 2025

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What antidepressant has the worst withdrawal symptoms?

What antidepressant has the worst withdrawal symptoms? Among the SSRIs paroxetine seems to be the worst offender and fluoxetine the least while sertraline and fluvoxamine tend to be intermediate. However, the most serious discontinuation reactions came from the SNRI venlafaxine. These drugs include paroxetine and fluvoxamine, which cause discontinuation syndrome in about 7% of people.

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